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Overview of selected projects

COMBACTE-MAGNET - Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections

 

COMBACTE-Magnet is a consortium within the joint research project COMBACTE of the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Innovative Medicine Initiative (IMI) and the European Union (EU).

Focusing on the critically ill patients being treated in intensive-care units, this project aims to find better options to deal with the threat of ICU-associated infections caused by gram-negative bacteria such as Pseudomonas aerigunosa.

 

In collaboration with clinicians, epidemiologists and pharmacists our group develops mathematical models to describe the burden of ICU-associated infections. Accounting for challenges such as the time-dependency of exposure and outcome as well as the competing risks setting, we provide innovative models that allow an unbiased quantification of effects on mortality, length of ICU stay, costs and treatment.

 

Principal Investigator: Martin Wolkewitz

Contributor: Derek Hazard, Maja von Cube, Susanne Weber, Klaus Kaier

                                               

SWISSNOSO

 

Prevalence studies to measure exposure to health-associated infections (HAIs) have a long tradition in the field of infection prevention and control. The pioneering study "Study on the Efficacy of Nosocomial Infection Control" (SENIC), initiated by the US Centers for Disease Control and Prevention (CDC) in the 1970s, has clearly demonstrated the benefits of HAI surveillance. The HAI prevalence at this time was estimated at about 5.2%. In 1981, the World Health Organization (WHO) convened a Consultative Group to monitor, control and prevent HAIs. In particular, the group recommended conducting HAI prevalence studies to assess the burden of the problem in different parts of the world.

More recently, the European Center for Disease Prevention and Control (ECDC) and the CDC have carried out large point prevalence surveys in Europe and the United States. Most local, regional and national surveys used point prevalence methodology, i.e. only HAIs active on the day of the survey will be considered.

The "swissnoso PPS 2017" project is a prevalence survey of HAIs in Switzerland

to obtain representative data on HAIs in acute care hospitals

to obtain data on antibiotic use in acute care hospitals

to estimate the attributable mortality due to HAIs

to estimate the costs of healthcare-associated infections

 

  • Principal Investigator: Martin Wolkewitz

    Contributor: Sam Doerken

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COMBACTE-NET - Combatting Bacterial Resistance in Europe: Networks to improve clinical trials for antibacterials

 

COMBACTE-Net is a consortium within the joint research project COMBACTE of the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Innovative Medicine Initiative (IMI) and the European Union (EU).

The aim of COMBACTE-Net is to create strong clinical, laboratory and research networks across Europe. Part of the work of COMBACTE-Net is to perform clinical studies. Two of those studies are the prospective observational studies ASPIRE-ICU and ASPIRE-SSI (Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa Infections in EuRopE). ASPIRE-ICU investigates the incidence of S.aureus and P.aeruginosa intensice care unit (ICU) pneumonia, and ventilator-associated pneumonia. The aim is to assess association with patient-related and contextual factors. ASPIRE-SSI investigates the incidence of S.aureus surgical site infection (SSI). The aim is to identify risk factors and develop a robust S.aureus SSI prediction. The settings considered in both studies lead to different statistical challenges, such as competing risks. The task of our group is to support the study teams in terms of consulting and analysis.


Principal Investigator: Martin Wolkewitz

Contributor: Susanne Weber, Derek Hazard

COMBACTE Net Logo

Other projects

 

For a list of all current projects please see here...

For a list of finished projects please see here...